Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications

M de Lera Ruiz, RL Kraus - Journal of medicinal chemistry, 2015 - ACS Publications
The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

[HTML][HTML] An updated review of ciguatera fish poisoning: clinical, epidemiological, environmental, and public health management

MA Friedman, M Fernandez, LC Backer, RW Dickey… - Marine drugs, 2017 - mdpi.com
Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the
world. It causes substantial human health, social, and economic impacts. The illness …

Does climate change increase the risk of marine toxins? Insights from changing seawater conditions

R Meng, X Du, K Ge, C Wu, Z Zhang, X Liang… - Archives of …, 2024 - Springer
Marine toxins produced by marine organisms threaten human health and impose a heavy
public health burden on coastal countries. Lately, there has been an emergence of marine …

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

E Decrock, M De Bock, N Wang, G Bultynck… - Cellular and Molecular …, 2015 - Springer
The central nervous system (CNS) is composed of a highly heterogeneous population of
cells. Dynamic interactions between different compartments (neuronal, glial, and vascular …

[HTML][HTML] The dual face of connexin-based astroglial Ca2+ communication: a key player in brain physiology and a prime target in pathology

M De Bock, E Decrock, N Wang, M Bol… - … et Biophysica Acta (BBA …, 2014 - Elsevier
For decades, studies have been focusing on the neuronal abnormalities that accompany
neurodegenerative disorders. Yet, glial cells are emerging as important players in numerous …

Neurological disturbances of ciguatera poisoning: clinical features and pathophysiological basis

K L'Herondelle, M Talagas, O Mignen, L Misery… - Cells, 2020 - mdpi.com
Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused
by the consumption of tropical and subtropical fish contaminated with potent neurotoxins …

Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Clinical Characterization and Follow-Up of a Mass Poisoning Event in Nuku Hiva …

CM Gatti, D Lonati, HT Darius, A Zancan, M Roué… - Toxins, 2018 - mdpi.com
Ciguatera fish poisoning (CFP) is the most prevalent non-bacterial food-borne form of
poisoning in French Polynesia, which results from the consumption of coral reef fish …

Developmental toxicity and molecular responses of marine medaka (Oryzias melastigma) embryos to ciguatoxin P-CTX-1 exposure

M Yan, PTY Leung, JCH Ip, J Cheng, JJ Wu, JR Gu… - Aquatic Toxicology, 2017 - Elsevier
Ciguatoxins are produced by toxic benthic dinoflagellates and cause ciguatera fish
poisoning worldwide, but the toxic effects on develo** marine fish have not been well …

From nociception to pain perception, possible implications of astrocytes

F Higinio-Rodríguez, A Rivera-Villaseñor… - Frontiers in cellular …, 2022 - frontiersin.org
Astrocytes are determinants for the functioning of the CNS. They respond to neuronal activity
with calcium increases and can in turn modulate synaptic transmission, brain plasticity as …

Ladder-shaped ion channel ligands: Current state of knowledge

YB Shmukler, DA Nikishin - Marine drugs, 2017 - mdpi.com
Ciguatoxins (CTX) and brevetoxins (BTX) are polycyclic ethereal compounds
biosynthesized by the worldwide distributed planktonic and epibenthic dinoflagellates of …