Intracellular deposition of aggregated and ubiquitylated proteins is a prominent
cytopathological feature of most neurodegenerative disorders. Whether protein aggregates …

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …

Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Transcriptional activation of a gene involves an orchestrated recruitment of components of
the basal transcription machinery and intermediate factors, concomitant with an alteration in …

Protein ubiquitylation is a recognized signal for protein degradation. However, it is
increasingly realized that ubiquitin conjugation to proteins can be used for many other …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …

Recently, many of the enzymes responsible for the addition and removal of ubiquitin from
the histones H2A and H2B have been identified and characterized. From these studies, it …

H2B ubiquitylation has been implicated in active transcription but is not well understood in
mammalian cells. Beyond earlier identification of hBRE1 as the E3 ligase for H2B …

Human telomere maintenance is essential for the protection of chromosome ends, and
changes in telomere length have been implicated in ageing and cancer,,,. Human telomere …