Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Introduction: Currently the treatment of chronic pain is inadequate and compromised by
debilitating central nervous system side effects. Here we discuss new therapeutic strategies …

Control of chronic pain is frequently inadequate and/or associated with intolerable adverse
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …

Heat exchange processes between the body and the environment are introduced. The
definition of the thermoneutral zone as the ambient temperature range within which body …

Preclinical research has recently uncovered new molecular mechanisms underlying the
generation and transduction of pain, many of which represent opportunities for …