Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A 1, A 2A, A 2B, and A 3. The A 2A and A 2B …

The adenosine A3 receptor (A3AR), a key member of the G protein-coupled receptor family,
is a promising therapeutic target for inflammatory and cancerous conditions. The selective …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous
adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine …

Four adenosine receptor subtypes of the family of G protein-coupled receptors, designated A
1, A 2A, A 2B and A 3 are currently known. In this study all human subtypes were stably …

The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …

Adenosine is an endogenous nucleoside that modulates many physiological processes. Its
actions are mediated by interaction with specific cell membrane receptors. Four subtypes of …