Orthologues and paralogues are types of homologous genes that are related by speciation
or duplication, respectively. Orthologous genes are generally assumed to retain equivalent …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

Gut microbiota are shaped by a combination of ecological and evolutionary forces. While the
ecological dynamics have been extensively studied, much less is known about how species …

Background The availability of multiple, essentially complete genome sequences of
prokaryotes and eukaryotes spurred both the demand and the opportunity for the …

Functional links between proteins can often be inferred from genomic associations between
the genes that encode them: groups of genes that are required for the same function tend to …

The repeated occurrence of genes in each other's neighbourhood on genomes has been
shown to indicate a functional association between the proteins they encode. Here we …

Comprehensive protein–protein interaction maps promise to reveal many aspects of the
complex regulatory network underlying cellular function. Recently, large-scale approaches …

Background Sequencing the genomes of multiple, taxonomically diverse eukaryotes
enables in-depth comparative-genomic analysis which is expected to help in reconstructing …

Interaction detection methods have led to the discovery of thousands of interactions between
proteins, and discerning relevance within large‐scale data sets is important to present‐day …

Although bacteria increase their DNA content through horizontal transfer and gene
duplication, their genomes remain small and, in particular, lack nonfunctional sequences …