Novel sequencing technologies are making it increasingly possible to measure the mutation
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …

High accuracy (fidelity) of DNA replication is important for cells to preserve the genetic
identity and to prevent the accumulation of deleterious mutations. The error rate during DNA …

Increased mutation rates under stress allow bacterial populations to adapt rapidly to
stressors, including antibiotics. Here we evaluate existing models for the evolution of stress …

Evolutionary theory assumed that mutations occur constantly, gradually, and randomly over
time. This formulation from the “modern synthesis” of the 1930s was embraced decades …

Basic ideas about the constancy and randomness of mutagenesis that drives evolution were
challenged by the discovery of mutation pathways activated by stress responses. These …

In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in
motion a series of different DNA repair and damage tolerance pathways. DNA polymerase …

Exposure to antibiotics induces the expression of mutagenic bacterial stress–response
pathways, but the evolutionary benefits of these responses remain unclear. One possibility is …

Faithful replication and maintenance of the genome are essential to the ability of any
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …

The secondary metabolites of polypropanoids, methyleugenol (MEG), and estragole (EG),
found in many herbs and spices, are commonly used as food flavoring agents and as …

Reversible protein phosphorylation is the most common type of epigenetic posttranslational
modification in living cells used as a major regulation mechanism of biological processes …