Brain organoids: advances, applications and challenges
Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
3D cell cultures: evolution of an ancient tool for new applications
A Cacciamali, R Villa, S Dotti - Frontiers in Physiology, 2022 - frontiersin.org
Recently, research is undergoing a drastic change in the application of the animal model as
a unique investigation strategy, considering an alternative approach for the development of …
a unique investigation strategy, considering an alternative approach for the development of …
A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
The choroid plexus and its role in the pathogenesis of neurological infections
D Thompson, CA Brissette, JA Watt - Fluids and Barriers of the CNS, 2022 - Springer
The choroid plexus is situated at an anatomically and functionally important interface within
the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the …
the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the …
Modeling neurological diseases with human brain organoids
H Wang - Frontiers in synaptic neuroscience, 2018 - frontiersin.org
The complexity and delicacy of human brain make it challenging to recapitulate its
development, function and disorders. Brain organoids derived from human pluripotent stem …
development, function and disorders. Brain organoids derived from human pluripotent stem …
Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins
Zika virus (ZIKV) directly infects neural progenitors and impairs their proliferation. How ZIKV
interacts with the host molecular machinery to impact neurogenesis in vivo is not well …
interacts with the host molecular machinery to impact neurogenesis in vivo is not well …
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang… - Cell research, 2019 - nature.com
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global
public health crisis since 2015. ZIKV preferentially infects and targets human neural …
public health crisis since 2015. ZIKV preferentially infects and targets human neural …
Zika virus neuropathogenesis: The different brain cells, host factors and mechanisms involved
Zika virus (ZIKV), despite being discovered six decades earlier, became a major health
concern only after an epidemic in French Polynesia and an increase in the number of …
concern only after an epidemic in French Polynesia and an increase in the number of …
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons
The harmful effects of ZIKA virus (ZIKV) infection are reflected by severe neurological
manifestations such as microcephaly in neonates and other complications associated with …
manifestations such as microcephaly in neonates and other complications associated with …
Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target
Z He, S An, J Chen, S Zhang, C Tan, J Yu, H Ye… - Proceedings of the …, 2020 - pnas.org
Mounting evidence has associated Zika virus (ZIKV) infection with congenital malformations,
including microcephaly, which raises global alarm. Nonetheless, mechanisms by which …
including microcephaly, which raises global alarm. Nonetheless, mechanisms by which …