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Towards a comprehensive catalogue of validated and target-linked human enhancers
The human gene catalogue is essentially complete, but we lack an equivalently vetted
inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers …
inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers …
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges
All cells possess an internal stress response to cope with environmental and
pathophysiological challenges. Upon stress, cells reprogram their molecular functions to …
pathophysiological challenges. Upon stress, cells reprogram their molecular functions to …
Nascent RNA analyses: tracking transcription and its regulation
The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …
genome. Decoding of this information begins with regulated transcription of genomic DNA …
Transcriptional reprogramming at the intersection of the heat shock response and proteostasis
Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors.
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …
Molecular mechanisms of heat shock factor 1 regulation
To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in
the face of adverse environmental conditions or radical restructuring of the proteome during …
the face of adverse environmental conditions or radical restructuring of the proteome during …
Molecular mechanisms driving transcriptional stress responses
Proteotoxic stress, that is, stress caused by protein misfolding and aggregation, triggers the
rapid and global reprogramming of transcription at genes and enhancers. Genome-wide …
rapid and global reprogramming of transcription at genes and enhancers. Genome-wide …
Roles of heat shock factor 1 beyond the heat shock response
Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …
[HTML][HTML] Stress-induced nuclear condensation of NELF drives transcriptional downregulation
In response to stress, human cells coordinately downregulate transcription and translation of
housekee** genes. To downregulate transcription, the negative elongation factor (NELF) …
housekee** genes. To downregulate transcription, the negative elongation factor (NELF) …
Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers
Abstract Eukaryotic RNA polymerase II (Pol II) has been found at both promoters and distal
enhancers, suggesting additional functions beyond mRNA production. To understand this …
enhancers, suggesting additional functions beyond mRNA production. To understand this …
Enhancer RNA: What we know and what we can achieve
Enhancers are important cis‐acting elements that can regulate gene transcription and cell
fate alongside promoters. In fact, many human cancers and diseases are associated with the …
fate alongside promoters. In fact, many human cancers and diseases are associated with the …