Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet,
seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of …

Glioblastoma is a highly lethal brain cancer with a median survival rate of less than 15
months when treated with the current standard of care, which consists of surgery …

A deletion variant of epidermal growth factor receptor (EGFRvIII) is a known driver mutation
in a subset of primary and secondary glioblastoma multiforme. Adoptive transfer of …

Glioblastoma is the most aggressive and the most common primary malignant brain tumor in
adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally …

Gliomas are one of the most common types of primary brain tumors and have remained
particularly challenging to treat. This review illustrates a multidisciplinary approach to the …

Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …

Adoptive T‐cell therapy (ACT) is a potent and flexible cancer treatment modality that can
induce complete, durable regression of certain human malignancies. Long‐term follow‐up …

Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide
substitutions and epigenetic modifications that drive malignant transformation. The Cancer …

There is a wide variety of cancer types yet, all share some common cellular and molecular
behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to …