Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow
obstruction, airway remodelling (measurable structural change) and inflammation. The …

All patients with asthma are at risk of having exacerbations. Hospitalizations and emergency
department (ED) visits account for a large proportion of the health-care cost burden of …

In April 2019, the Global Initiative for Asthma (GINA)(box 1) published new
recommendations that might be considered the most fundamental change in asthma …

Background International time trends in asthma mortality have been strongly affected by
changes in management and in particular drug treatments. However, little is known about …

Rationale: Increased thickness of the airway smooth muscle (ASM) layer in asthma may
result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix …

Summary Background The Single combination budesonide–formoterol inhaler Maintenance
And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients …

Background According to international treatment guidelines, inhaled rapid-acting β 2
agonists should be used for the control of symptoms in patients with asthma. We compared …

Short-acting β-adrenergic receptor agonists have pharmacologically predictable dose-
related and potency-related adverse effects, including tachycardia and tremor, and they also …

BACKGROUND: Little is known about the effect of age on acute asthma outcomes.
OBJECTIVE: We sought to investigate age-related differences in the emergency department …

Asthma is characterised by an increased airway smooth muscle (ASM) area (ASMarea)
within the airway wall. The present study examined the relationship of factors including …