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The intricate role of CXCR4 in cancer
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks
Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …
Molecular mechanisms and clinical management of cancer bone metastasis
As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …
CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression
Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …
protein-coupled seven-span transmembrane receptors, are major regulators of cell …
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Signals from the microenvironment have a profound influence on the maintenance and/or
progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived …
progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived …
Chemokines in homeostasis and diseases
For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …
migration during immune surveillance, development, inflammation and cancer progression …
CXCL12 (SDF1α)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Addition of multiple molecularly targeted agents to the existing armamentarium of
chemotherapeutics and radiotherapies represents a significant advance in the management …
chemotherapeutics and radiotherapies represents a significant advance in the management …
The SDF-1–CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis
Pro-angiogenic bone marrow (BM) cells include subsets of hematopoietic cells that provide
vascular support and endothelial progenitor cells (EPCs), which under certain permissive …
vascular support and endothelial progenitor cells (EPCs), which under certain permissive …
Small molecule inhibitors of CXCR4
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …
Cancer-associated fibroblasts: a multifaceted driver of breast cancer progression
H Luo, G Tu, Z Liu, M Liu - Cancer letters, 2015 - Elsevier
Cancerous tissue is a complex mix of tumor cells, stromal cells and extracellular matrix
(ECM), all of which make up a disordered and aggressive niche in comparison with …
(ECM), all of which make up a disordered and aggressive niche in comparison with …