Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

[HTML][HTML] Dietary curcumin: correlation between bioavailability and health potential

M Dei Cas, R Ghidoni - Nutrients, 2019 - mdpi.com
The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a
broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer …

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

M Zusso, V Lunardi, D Franceschini, A Pagetta… - Journal of …, 2019 - Springer
Background Neuroinflammation is the response of the central nervous system to events that
interfere with tissue homeostasis and represents a common denominator in virtually all …

Neuroprotective herbs for the management of Alzheimer's disease

J Gregory, YV Vengalasetti, DE Bredesen, RV Rao - Biomolecules, 2021 - mdpi.com
Background—Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative
disease that is characterized by memory loss, personality changes, and a decline in …

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

SS Patel, A Acharya, RS Ray, R Agrawal… - Critical reviews in …, 2020 - Taylor & Francis
Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

S Abrahams, WL Haylett, G Johnson, JA Carr… - Neuroscience, 2019 - Elsevier
The global burden of neurodegenerative disorders has increased substantially over the past
2 decades due to rising rates of population aging. Although neurodegenerative disorders …

Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease

Y Koronyo, D Biggs, E Barron, DS Boyer… - JCI …, 2017 - pmc.ncbi.nlm.nih.gov
BACKGROUND. Noninvasive detection of Alzheimer's disease (AD) with high specificity and
sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective …

Curcumin and health

M Pulido-Moran, J Moreno-Fernandez… - Molecules, 2016 - mdpi.com
Nowadays, there are some molecules that have shown over the years a high capacity to act
against relevant pathologies such as cardiovascular disease, neurodegenerative disorders …

Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

G Caruso, SA Torrisi, MP Mogavero, W Currenti… - Pharmacology & …, 2022 - Elsevier
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …