Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …

In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in
numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is …

Microtubules, the primary components of the chromosome segregation machinery, are
stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits …

This Commentary will describe the goal of develo** and implementing novel, powerful,
and integrated multiscale computer simulation methodology capable of accessing the large …

Microtubules are amazing filaments made of GTPase enzymes that store energy used for
their own self‐destruction to cause a stochastically driven dynamics called dynamic …

Thirteen tubulin protofilaments, made of αβ-tubulin heterodimers, interact laterally to
produce cytoskeletal microtubules. Microtubules exhibit the striking property of dynamic …

Microtubules (MTs) are key components of the cytoskeleton and play a central role in cell
division and development. MT assembly is known to be associated with a structural change …

Microtubules (MTs), mesoscopic cellular filaments, grow primarily by the addition of GTP-
bound tubulin dimers at their dynamic flaring plus-end tips. MTs can perform mechanical …

The structure and free energy of multistranded linear polymer ends evolves as individual
subunits are added and lost. Thus, the energetic state of the polymer end is not constant, as …

Natural microtubules typically include one A-lattice seam within an otherwise helically
symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule …