LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …

A major component of consolidation theory holds that protein synthesis is required to
produce the synaptic modification needed for long-term memory storage. Protein synthesis …

Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null
mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac …

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism
for the establishment of certain forms of explicit memory in the mammalian brain. As is the …

Substantial insight has recently been achieved into the mechanisms responsible for the
generation of left–right (L–R) asymmetry in the vertebrate body plan,,,. However, the …

Protein kinases critically regulate synaptic plasticity in the mammalian hippocampus. Cyclic-
AMP dependent protein kinase (PKA) is a serine–threonine kinase that has been strongly …

A diverse family of transcription factors bind to the cAMP-response elements found in a
variety of mammalian and viral gene promoters. One of the members of this family, CREB, is …

Following the initial demonstration of phosphorylation of endogenous brain proteins
(Johnson et al., 1971), two decades of work have shown that this biochemical mechanism …

Synaptic transmission was examined in Drosophila mutants deficient in memory function.
These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine …

More Americans are consuming diets higher in saturated fats and refined sugars than ever
before. These trends could have serious consequences for the older population because …