ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors

PJ Sáez, P Vargas, KF Shoji, PA Harcha… - Science …, 2017 - science.org
Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

Connexins and pannexins in bone and skeletal muscle

LI Plotkin, HM Davis, BA Cisterna, JC Sáez - Current osteoporosis reports, 2017 - Springer
Purpose of review To discuss current knowledge on the role of connexins and pannexins in
the musculoskeletal system. Recent findings Connexins and pannexins are crucial for the …

Oxidative stress, inflammation and connexin hemichannels in muscular dystrophies

A González-Jamett, W Vásquez, G Cifuentes-Riveros… - Biomedicines, 2022 - mdpi.com
Muscular dystrophies (MDs) are a heterogeneous group of congenital neuromuscular
disorders whose clinical signs include myalgia, skeletal muscle weakness, hypotonia, and …

A Chemist's guide to multi-objective optimization solvers for reaction optimization

AS Vel, D Cortés-Borda, FX Felpin - Reaction Chemistry & Engineering, 2024 - pubs.rsc.org
Recently, multi-objective optimization has garnered significant attention in the field of
reaction optimization. Various multi-objective optimization solvers, such as MVMOO …

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis

LA Cea, C Puebla, BA Cisterna, R Escamilla… - Cellular and Molecular …, 2016 - Springer
Skeletal muscles of patients with Duchenne muscular dystrophy (DMD) show numerous
alterations including inflammation, apoptosis, and necrosis of myofibers. However, the …

Pannexins in the musculoskeletal system: new targets for development and disease progression

Y Luo, S Zheng, W **ao, H Zhang, Y Li - Bone Research, 2024 - nature.com
During cell differentiation, growth, and development, cells can respond to extracellular
stimuli through communication channels. Pannexin (Panx) family and connexin (Cx) family …

Regulation of skeletal muscle myoblast differentiation and proliferation by pannexins

S Langlois, KN Cowan - Protein Reviews: Volume 17, 2017 - Springer
Pannexins are newly discovered channels that are now recognized as mediators of
adenosine triphosphate release from several cell types allowing communication with the …

Sex‐dependent role of Pannexin 1 in regulating skeletal muscle and satellite cell function

E Freeman, S Langlois, K Scott… - Journal of Cellular …, 2022 - Wiley Online Library
The development and regeneration of skeletal muscle are mediated by satellite cells (SCs),
which ensure the efficient formation of myofibers while repopulating the niche that allows …

Expression of Pannexin 1 and Pannexin 3 during skeletal muscle development, regeneration, and Duchenne muscular dystrophy

TL Pham, ME St‐Pierre… - Journal of Cellular …, 2018 - Wiley Online Library
Pannexin 1 (Panx1) and Pannexin 3 (Panx3) are single membrane channels recently
implicated in myogenic commitment, as well as myoblast proliferation and differentiation in …

Pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders

W Vásquez, CA Toro, CP Cardozo… - The Journal of …, 2024 - Wiley Online Library
A growing body of research has provided evidence that de novo expression of connexin
hemichannels and upregulation of pannexin hemichannels (Cx HCs and Panx HCs …