The role of regulatory variation in complex traits and disease
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Into the eye of the cytokine storm
JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …
alike, and while the general notion of an excessive or uncontrolled release of …
Rare and common variants: twenty arguments
G Gibson - Nature Reviews Genetics, 2012 - nature.com
Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …
SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon
AL Totura, RS Baric - Current opinion in virology, 2012 - Elsevier
SARS-CoV is a pathogenic coronavirus that emerged from a zoonotic reservoir, leading to
global dissemination of the virus. The association SARS-CoV with aberrant cytokine …
global dissemination of the virus. The association SARS-CoV with aberrant cytokine …
Finding the sources of missing heritability in a yeast cross
For many traits, including susceptibility to common diseases in humans, causal loci
uncovered by genetic-map** studies explain only a minority of the heritable contribution to …
uncovered by genetic-map** studies explain only a minority of the heritable contribution to …
MAGIC populations in crops: current status and future prospects
Key message MAGIC populations present novel challenges and opportunities in crops due
to their complex pedigree structure. They offer great potential both for dissecting genomic …
to their complex pedigree structure. They offer great potential both for dissecting genomic …
Multi-parent advanced generation inter-cross (MAGIC) populations in rice: progress and potential for genetics research and breeding
Background This article describes the development of Multi-parent Advanced Generation
Inter-Cross populations (MAGIC) in rice and discusses potential applications for map** …
Inter-Cross populations (MAGIC) in rice and discusses potential applications for map** …
The genome architecture of the Collaborative Cross mouse genetic reference population
Collaborative Cross Consortium - Genetics, 2012 - academic.oup.com
Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Obesity genetics in mouse and human: back and forth, and back again
Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …
interplay between predisposing genes and environmental stimuli. Current attempts to …