Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …

A review of curcumin and its derivatives as anticancer agents

MA Tomeh, R Hadianamrei, X Zhao - International journal of molecular …, 2019 - mdpi.com
Cancer is the second leading cause of death in the world and one of the major public health
problems. Despite the great advances in cancer therapy, the incidence and mortality rates of …

Potential role of curcumin and its nanoformulations to treat various types of cancers

MT Kabir, MH Rahman, R Akter, T Behl, D Kaushik… - Biomolecules, 2021 - mdpi.com
Cancer is a major burden of disease globally. Each year, tens of millions of people are
diagnosed with cancer worldwide, and more than half of the patients eventually die from it …

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

AB Kunnumakkara, D Bordoloi… - British journal of …, 2017 - Wiley Online Library
Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment

C Bertoncini-Silva, A Vlad, R Ricciarelli… - Antioxidants, 2024 - mdpi.com
Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main
bioactive component of turmeric spice and has gained increasing interest due to its …

Curcumin and colorectal cancer: from basic to clinical evidences

M Pricci, B Girardi, F Giorgio, G Losurdo… - International journal of …, 2020 - mdpi.com
Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria,
and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been …

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

AB Kunnumakkara, D Bordoloi, C Harsha… - Clinical …, 2017 - portlandpress.com
Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and
Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical …

[HTML][HTML] Curcumin: An age-old anti-inflammatory and anti-neoplastic agent

MC Fadus, C Lau, J Bikhchandani, HT Lynch - Journal of traditional and …, 2017 - Elsevier
Curcumin is a natural anti-inflammatory agent that has been used for treating medical
conditions for many years. Several experimental and pharmacologic trials have …

[HTML][HTML] Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial

LM Howells, COO Iwuji, GRB Irving, S Barber… - The Journal of …, 2019 - Elsevier
Background Curcumin is the main active ingredient of the spice turmeric, investigated
extensively for putative anticancer properties. Objectives This phase IIa open-labelled …

The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - Elsevier
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …