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SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
E Ferrannini, A Solini - Nature Reviews Endocrinology, 2012 - nature.com
This Review covers the rationale, physiological consequences and clinical application of
pharmacological sodium–glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 …
pharmacological sodium–glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 …
Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study
R Nahra, T Wang, KM Gadde, J Oscarsson… - Diabetes …, 2021 - diabetesjournals.org
OBJECTIVE Cotadutide, a dual GLP-1 and glucagon receptor agonist, is under development
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review
Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an
increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve …
increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve …
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending …
Background Weight loss is often key in the management of obese or overweight patients
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …
Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross‐national benchmarking of diabetes‐related psychosocial outcomes for people with diabetes
Abstract Aims The second Diabetes Attitudes, Wishes and Needs (DAWN 2) study aimed to
assess psychosocial outcomes in people with diabetes across countries for benchmarking …
assess psychosocial outcomes in people with diabetes across countries for benchmarking …
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
OBJECTIVE To investigate the efficacy and tolerability of empagliflozin as an add-on to
metformin therapy in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS …
metformin therapy in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS …
High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal
DADE Magalhães, WT Kume, FS Correia… - Anais da Academia …, 2019 - SciELO Brasil
Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat
diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control …
diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control …
Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity
Y Si, Y Zhao, H Hao, J Liu, Y Guo, Y Mu, J Shen… - Diabetes, 2012 - diabetesjournals.org
Infusion of mesenchymal stem cells (MSCs) has been shown to effectively lower blood
glucose in diabetic individuals, but the mechanism involved could not be adequately …
glucose in diabetic individuals, but the mechanism involved could not be adequately …
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
T Heise, E Seewaldt‐Becker, S Macha… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aim To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of
empagliflozin in patients with type 2 diabetes following oral administration of 10, 25 or 100 …
empagliflozin in patients with type 2 diabetes following oral administration of 10, 25 or 100 …
Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats
Background Diabetes is a major public health concern. In spite of continuous new drug
development to treat diabetes, herbal remedies remain a potential adjunct therapy to …
development to treat diabetes, herbal remedies remain a potential adjunct therapy to …