Current best practices in single‐cell RNA‐seq analysis: a tutorial
Single‐cell RNA‐seq has enabled gene expression to be studied at an unprecedented
resolution. The promise of this technology is attracting a growing user base for single‐cell …
resolution. The promise of this technology is attracting a growing user base for single‐cell …
Challenges in unsupervised clustering of single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
SARS-CoV-2 infection of the oral cavity and saliva
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …
A molecular cell atlas of the human lung from single-cell RNA sequencing
Although single-cell RNA sequencing studies have begun to provide compendia of cell
expression profiles,,,,,,,–, it has been difficult to systematically identify and localize all …
expression profiles,,,,,,,–, it has been difficult to systematically identify and localize all …
Construction of a human cell landscape at single-cell level
Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …
systems. However, a comprehensive single-cell atlas has not been achieved for humans …
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …