Since the 1990s the rising incidence of multiple drug resistant TB, particularly in the context
of human immunodeficiency virus co-infected patients, has threatened global TB control. At …

The growing interest on polymeric delivery systems for pulmonary administration of drugs
anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that …

LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple
activities including a mediator of vitamin D-induced autophagy in human macrophages …

Pulmonary drug delivery system is increasingly gaining popularity for several lung diseases
including tuberculosis (TB) due to its ability to attain high drug concentrations at the site of …

We investigated whether particles suitable for delivery to alveolar macrophages may provide
a means of targeting rapamycin, an inducer of autophagy, to alveolar macrophages as a …

Growing rates of tuberculosis (TB) superbugs are alarming, which has hampered the
progress made to-date to control this infectious disease, and new drug candidates are few …

Macrophages are large mononuclear phagocytic cells that play a vital role in the immune
response. They are present in all body tissues with extremely heterogeneous and plastic …

Introduction Nontuberculous mycobacteria (NTM) infections have emerged as a significant
clinical challenge due to their intrinsic multidrug resistance and the limited efficacy of …

Inhaled therapies offer a unique approach to the treatment of tuberculosis (TB) using a
relevant target organ system as a route of administration. The number of research reports on …

We investigated the preclinical efficacy and safety/tolerability of biodegradable polymeric
particles containing isoniazid (INH) and rifabutin (RFB) dry powder for inhalation (DPI) as an …