An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

NE Weisser, M Sanches, E Escobar-Cabrera… - Nature …, 2023 - nature.com
Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that plays an
oncogenic role in breast, gastric and other solid tumors. However, anti-HER2 therapies are …

State-of-the-art approaches for image deconvolution problems, including modern deep learning architectures

M Makarkin, D Bratashov - Micromachines, 2021 - mdpi.com
In modern digital microscopy, deconvolution methods are widely used to eliminate a number
of image defects and increase resolution. In this review, we have divided these methods into …

Novel optofluidic imaging system integrated with tunable microlens arrays

Y Zhong, H Yu, Y Wen, P Zhou, H Guo… - … Applied Materials & …, 2023 - ACS Publications
Optofluidic tunable microlens arrays (MLAs) can manipulate and control light propagation
using fluids. Lately, their applicability to miniature lab-on-a-chip systems is being extensively …

Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis

F Heinkel, L Abraham, M Ko, J Chao, H Bach… - Proceedings of the …, 2019 - pnas.org
Phase separation drives numerous cellular processes, ranging from the formation of
membrane-less organelles to the cooperative assembly of signaling proteins. Features such …

In situ spectroelectrochemical fluorescence microscopy for studying electrodes modified by molecular adsorbates

D Bizzotto - Current Opinion in Electrochemistry, 2018 - Elsevier
The complexity of the electrochemical interface when modified by molecular adsorbates can
be significant, especially those that are used for biosensing (eg, nucleic acids, proteins) …

Super-resolution modularity analysis shows polyhedral caveolin-1 oligomers combine to form scaffolds and caveolae

IM Khater, Q Liu, KC Chou, G Hamarneh, IR Nabi - Scientific reports, 2019 - nature.com
Abstract Caveolin-1 (Cav1), the coat protein for caveolae, also forms non-caveolar Cav1
scaffolds. Single molecule Cav1 super-resolution microscopy analysis previously identified …

Quinoline-containing diarylethenes: bridging between turn-on fluorescence, RGB switching and room temperature phosphorescence

Z Xu, QT Liu, X Wang, Q Liu, D Hean, KC Chou… - Chemical …, 2020 - pubs.rsc.org
Simple structural modifications using oxidation and methylation of a quinoline-containing
diarylethene result in dramatic variation of photophysical properties. Turn-on fluorescence …

A stochastic assembly model for Nipah virus revealed by super-resolution microscopy

Q Liu, L Chen, HC Aguilar, KC Chou - Nature communications, 2018 - nature.com
Understanding virus assembly mechanisms is important for develo** therapeutic
interventions. Nipah virus (NiV) is of interest because of its high mortality rate and efficient …

A mean shift algorithm for drift correction in localization microscopy

FJ Fazekas, TR Shaw, S Kim, RA Bogucki, SL Veatch - Biophysical reports, 2021 - cell.com
Single-molecule localization microscopy techniques transcend the diffraction limit of visible
light by localizing isolated emitters sampled stochastically. This time-lapse imaging …

High-precision 3D drift correction with differential phase contrast images

M Shang, Z Zhou, W Kuang, Y Wang, B **n… - Optics …, 2021 - opg.optica.org
Single molecule localization microscopy (SMLM) usually requires long image acquisition
time at the order of minutes and thus suffers from sample drift, which deteriorates image …