Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

A thorough interrogation of the immune landscape is crucial for immunotherapy strategy
selection and prediction of clinical responses in non-small-cell lung cancer (NSCLC) …

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear.
Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single …

Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor
microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of …

Quantifying aging rate is important for evaluating age-associated decline and mortality. A
blood single-cell RNA sequencing dataset for seven supercentenarians (SCs) was recently …

The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …

The clear cell renal cell carcinoma (ccRCC) microenvironment consists of many different cell
types and structural components that play critical roles in cancer progression and drug …

The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …