OBJECTIVE: Age-related changes in multiple components of the musculoskeletal system
may contribute to the well established link between aging and osteoarthritis (OA). This …

This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …

Aging is a natural process by which every single living organism approaches its twilight of
existence in a natural way. However, aging is also linked to the pathogenesis of a number of …

Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the
regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has …

The preservation of articular cartilage depends on kee** the cartilage architecture intact.
Cartilage strength and function depend on both the properties of the tissue and on their …

Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear.
Recent publications were reviewed to elucidate the connection between aging and OA. With …

Osteoarthritis (OA) is a common joint disease, mainly effecting the elderly population. The
cause of OA seems to be an imbalance in catabolic and anabolic factors that develops with …

Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA,
changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth …

Introduction: TGF‐β is a multifunctional regulator of chondrocyte proliferation, differentiation,
and extracellular matrix production. Dysregulation of TGF‐β action has been implicated in …

OBJECTIVE: The normal structure and function of articular cartilage are the result of a
precisely balanced interaction between anabolic and catabolic processes. The transforming …