Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

There are at least two types of cannabinoid receptors (CB 1 and CB 2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ 9 …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of nuclear hormone receptor superfamily comprising of the following three subtypes …

Peroxisome proliferator-activated receptor α is a potent regulator of systemic and cellular
metabolism and energy homeostasis, but it also suppresses various inflammatory reactions …

The endocannabinoid system is known to have positive effects on depression partly through
its actions on neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF). As BDNF is …

The therapeutic potential of cannabinoids has been the topic of extensive investigation
following the discovery of cannabinoid receptors and their endogenous ligands …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound
belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic …