Regulation of microRNA biogenesis

M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms

A Łabno, R Tomecki, A Dziembowski - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

To kill a microRNA: emerging concepts in target-directed microRNA degradation

AF Buhagiar, B Kleaveland - Nucleic Acids Research, 2024 - academic.oup.com
Abstract MicroRNAs (miRNAs) guide Argonaute (AGO) proteins to bind mRNA targets.
Although most targets are destabilized by miRNA–AGO binding, some targets induce …

A guide to miRNAs in inflammation and innate immune responses

C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …

Dysregulation of microRNA biogenesis and gene silencing in cancer

A Hata, J Lieberman - Science signaling, 2015 - science.org
MicroRNAs (miRNAs) are small noncoding RNAs that suppress the abundance of partially
complementary mRNAs and inhibit their translation. Each miRNA can regulate hundreds of …

MicroRNA turnover: when, how, and why

S Rüegger, H Großhans - Trends in biochemical sciences, 2012 - cell.com
MicroRNAs (miRNAs) are short (∼ 22 nucleotide) RNAs that are important for the regulation
of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly …

The biogenesis and regulation of animal microRNAs

H Kim, YY Lee, VN Kim - Nature Reviews Molecular Cell Biology, 2024 - nature.com
MicroRNAs (miRNAs) are small, yet profoundly influential, non-coding RNAs that base-pair
with mRNAs to induce RNA silencing. Although the basic principles of miRNA biogenesis …

Human mitochondrial RNA decay mediated by PNPase–hSuv3 complex takes place in distinct foci

LS Borowski, A Dziembowski… - Nucleic acids …, 2013 - academic.oup.com
RNA decay is usually mediated by protein complexes and can occur in specific foci such as
P-bodies in the cytoplasm of eukaryotes. In human mitochondria nothing is known about the …

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria

T Chujo, T Ohira, Y Sakaguchi, N Goshima… - Nucleic acids …, 2012 - academic.oup.com
In human mitochondria, 10 mRNAs species are generated from a long polycistronic
precursor that is transcribed from the heavy chain of mitochondrial DNA, in theory yielding …

MicroRNA degradation and turnover: regulating the regulators

Z Zhang, YW Qin, G Brewer… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important
regulatory roles in gene expression. The control of miRNA biogenesis has been well …