Unlocking the electrochemical functions of biomolecular condensates
Biomolecular condensation is a key mechanism for organizing cellular processes in a
spatiotemporal manner. The phase-transition nature of this process defines a density …
spatiotemporal manner. The phase-transition nature of this process defines a density …
Understanding hydrophobic effects: Insights from water density fluctuations
NB Rego, AJ Patel - Annual Review of Condensed Matter …, 2022 - annualreviews.org
The aversion of hydrophobic solutes for water drives diverse interactions and assemblies
across materials science, biology, and beyond. Here, we review the theoretical …
across materials science, biology, and beyond. Here, we review the theoretical …
Structure of FUS protein fibrils and its relevance to self-assembly and phase separation of low-complexity domains
Polymerization and phase separation of proteins containing low-complexity (LC) domains
are important factors in gene expression, mRNA processing and trafficking, and localization …
are important factors in gene expression, mRNA processing and trafficking, and localization …
Balanced protein–water interactions improve properties of disordered proteins and non-specific protein association
Some frequently encountered deficiencies in all-atom molecular simulations, such as
nonspecific protein–protein interactions being too strong, and unfolded or disordered states …
nonspecific protein–protein interactions being too strong, and unfolded or disordered states …
A pH-driven transition of the cytoplasm from a fluid-to a solid-like state promotes entry into dormancy
Cells can enter into a dormant state when faced with unfavorable conditions. However, how
cells enter into and recover from this state is still poorly understood. Here, we study …
cells enter into and recover from this state is still poorly understood. Here, we study …
Thermodynamic forces from protein and water govern condensate formation of an intrinsically disordered protein domain
Liquid-liquid phase separation (LLPS) can drive a multitude of cellular processes by
compartmentalizing biological cells via the formation of dense liquid biomolecular …
compartmentalizing biological cells via the formation of dense liquid biomolecular …
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose
pathological aggregation is implicated in neurodegenerative disorders, is not well …
pathological aggregation is implicated in neurodegenerative disorders, is not well …
Protein storytelling through physics
BACKGROUND Understanding biology, particularly at the level of actionable drug
discovery, is often a matter of develo** accurate stories about how proteins work. This …
discovery, is often a matter of develo** accurate stories about how proteins work. This …
Molecular crowding: the history and development of a scientific paradigm
It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …
crowded environment, that is, an environment populated by numerous different molecules …
Rational design of amyloid‐like fibrillary structures for tailoring food protein techno‐functionality and their potential health implications
KJA Jansens, I Rombouts, C Grootaert… - … Reviews in Food …, 2019 - Wiley Online Library
To control and enhance protein functionality is a major challenge for food scientists. In this
context, research on food protein fibril formation, especially amyloid fibril formation, holds …
context, research on food protein fibril formation, especially amyloid fibril formation, holds …