Coronary artery calcification: from mechanism to molecular imaging

T Nakahara, MR Dweck, N Narula, D Pisapia… - JACC: Cardiovascular …, 2017‏ - jacc.org
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence
of calcification may change portions of the arterial conduit to a noncompliant structure …

Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia

M Dewey, M Siebes, M Kachelrieß, KF Kofoed… - Nature Reviews …, 2020‏ - nature.com
Cardiac imaging has a pivotal role in the prevention, diagnosis and treatment of ischaemic
heart disease. SPECT is most commonly used for clinical myocardial perfusion imaging …

Prevalence of subclinical coronary artery atherosclerosis in the general population

G Bergström, M Persson, M Adiels, E Björnson… - Circulation, 2021‏ - ahajournals.org
Background: Early detection of coronary atherosclerosis using coronary computed
tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring …

Identification of high-risk plaques destined to cause acute coronary syndrome using coronary computed tomographic angiography and computational fluid dynamics

JM Lee, G Choi, BK Koo, D Hwang, J Park… - Cardiovascular …, 2019‏ - jacc.org
Objectives The authors investigated the utility of noninvasive hemodynamic assessment in
the identification of high-risk plaques that caused subsequent acute coronary syndrome …

Society of Cardiovascular Computed Tomography/North American Society of Cardiovascular Imaging–expert consensus document on coronary CT imaging of …

LJ Shaw, R Blankstein, JJ Bax, M Ferencik… - Journal of …, 2021‏ - Elsevier
Coronary computed tomographic angiography (CCTA) provides a wealth of clinically
meaningful information beyond anatomic stenosis alone, including the presence or absence …

Imaging atherosclerosis

JM Tarkin, MR Dweck, NR Evans, RAP Takx… - Circulation …, 2016‏ - ahajournals.org
Advances in atherosclerosis imaging technology and research have provided a range of
diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular …

Radiomic features are superior to conventional quantitative computed tomographic metrics to identify coronary plaques with napkin-ring sign

M Kolossváry, J Karády, B Szilveszter… - Circulation …, 2017‏ - ahajournals.org
Background—Napkin-ring sign (NRS) is an independent prognostic imaging marker of
major adverse cardiac events. However, identification of NRS is challenging because of its …

Role of biomechanical forces in the natural history of coronary atherosclerosis

AJ Brown, Z Teng, PC Evans, JH Gillard… - Nature reviews …, 2016‏ - nature.com
Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

The role of matrix metalloproteinase‐9 in atherosclerotic plaque instability

T Li, X Li, Y Feng, G Dong, Y Wang… - Mediators of …, 2020‏ - Wiley Online Library
Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

Prognostic implications of plaque characteristics and stenosis severity in patients with coronary artery disease

JM Lee, KH Choi, BK Koo, J Park, J Kim… - Journal of the American …, 2019‏ - jacc.org
Background: Although the presence of ischemia is a key prognostic factor in patients with
coronary artery disease, the presence of high-risk plaque characteristics (HRPC) is also …