Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

Biomimetic antimicrobial polymers: Recent advances in molecular design

C Ergene, K Yasuhara, EF Palermo - Polymer Chemistry, 2018 - pubs.rsc.org
The increasing prevalence of antibiotic-resistant bacterial infections, coupled with the
decline in the number of new antibiotic drug approvals, has created a therapeutic gap that …

Helical polymers for biological and medical applications

T Leigh, P Fernandez-Trillo - Nature Reviews Chemistry, 2020 - nature.com
Helices are the most prevalent secondary structure in biomolecules and play vital roles in
their activity. Chemists have been fascinated with mimicking this molecular conformation …

Antimicrobial susceptibility testing of antimicrobial peptides to better predict efficacy

DK Mercer, MDT Torres, SS Duay, E Lovie… - Frontiers in cellular …, 2020 - frontiersin.org
During the development of antimicrobial peptides (AMP) as potential therapeutics,
antimicrobial susceptibility testing (AST) stands as an essential part of the process in …

Photo‐Enhanced Antimicrobial Activity of Polymers Containing an Embedded Photosensitiser

PR Judzewitsch, N Corrigan, EHH Wong… - Angewandte …, 2021 - Wiley Online Library
This work presents the synthesis of a novel photosensitive acrylate monomer for use as both
a self‐catalyst in the photoinduced electron/energy transfer–reversible addition …

Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities

Q Zhang, P Ma, J **e, S Zhang, X **ao, Z Qiao… - Biomaterials …, 2019 - pubs.rsc.org
Microbial infections have always been serious challenges to human health considering that
antibiotics almost inevitably induce microbial resistance. Therefore, it is urgent to develop a …

Sequence control as a powerful tool for improving the selectivity of antimicrobial polymers

A Kuroki, P Sangwan, Y Qu, R Peltier… - … applied materials & …, 2017 - ACS Publications
Antimicrobial polymers appear as a promising alternative to tackle the current development
of bacterial resistance against conventional antibiotics as they rely on bacterial membrane …

Synthetic star nanoengineered antimicrobial polymers as antibiofilm agents: Bacterial membrane disruption and cell aggregation

S Laroque, R Garcia Maset, A Hapeshi… - …, 2023 - ACS Publications
Antimicrobial resistance has become a worldwide issue, with multiresistant bacterial strains
emerging at an alarming rate. Multivalent antimicrobial polymer architectures such as bottle …

Facial amphiphilicity-induced polymer nanostructures for antimicrobial applications

MA Rahman, MS Jui, M Bam, Y Cha… - … applied materials & …, 2020 - ACS Publications
New antimicrobial agents are needed to address ever-increasing antimicrobial resistance
and a growing epidemic of infections caused by multidrug resistant pathogens. We design …

Impact of multivalence and self-assembly in the design of polymeric antimicrobial peptide mimics

S Laroque, M Reifarth, M Sperling… - … applied materials & …, 2020 - ACS Publications
Antimicrobial resistance is an increasingly serious challenge for public health and could
result in dramatic negative consequences for the health care sector during the next decades …