[HTML][HTML] Diagnostic and prognostic biomarkers in renal clear cell carcinoma

C Weaver, K Bin Satter, KP Richardson, LKH Tran… - Biomedicines, 2022 - mdpi.com
Renal clear cell carcinoma (ccRCC) comprises over 75% of all renal tumors and arises in
the epithelial cells of the proximal convoluted tubule. Molecularly ccRCC is characterized by …

Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology

W Michno, PM Wehrli, K Blennow… - Journal of …, 2019 - Wiley Online Library
Recent advances in the understanding of basic pathological mechanisms in various
neurological diseases depend directly on the development of novel bioanalytical …

High‐resolution MALDI‐FT‐ICR MS imaging for the analysis of metabolites from formalin‐fixed, paraffin‐embedded clinical tissue samples

A Buck, A Ly, B Balluff, N Sun, K Gorzolka… - The Journal of …, 2015 - Wiley Online Library
We present the first analytical approach to demonstrate the in situ imaging of metabolites
from formalin‐fixed, paraffin‐embedded (FFPE) human tissue samples. Using high …

Spatial multiomics of lipids, N-glycans, and tryptic peptides on a single FFPE tissue section

V Denti, G Capitoli, I Piga, F Clerici… - Journal of proteome …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) is an emerging technology that is capable of map**
various biomolecules within their native spatial context, and performing spatial multiomics …

Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging

J Hermann, H Noels, W Theelen, M Lellig… - Analytical and …, 2020 - Springer
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MALDI
MSI) has become a powerful tool with a high potential relevance for the analysis of …

Mass spectrometry imaging, laser capture microdissection, and LC-MS/MS of the same tissue section

M Dilillo, D Pellegrini, R Ait-Belkacem… - Journal of proteome …, 2017 - ACS Publications
Mass spectrometry imaging (MSI) is able to simultaneously record the distributions of
hundreds of molecules directly from tissue. Rapid direct tissue analysis is essential for MSI …

Antigen retrieval and its effect on the MALDI-MSI of lipids in formalin-fixed paraffin-embedded tissue

V Denti, I Piga, S Guarnerio, F Clerici… - Journal of the …, 2020 - ACS Publications
Formalin-fixed paraffin-embedded (FFPE) tissue represents the primary source of clinical
tissue and is routinely used in MALDI-MSI studies. However, it is not particularly suitable for …

Applications of spatially resolved omics in the field of endocrine tumors

Y Hou, Y Gao, S Guo, Z Zhang, R Chen… - Frontiers in …, 2023 - frontiersin.org
Endocrine tumors derive from endocrine cells with high heterogeneity in function, structure
and embryology, and are characteristic of a marked diversity and tissue heterogeneity …

Feasibility of MALDI-MSI-Based Proteomics Using Bouin-Fixed Pathology Samples: Untap** the Goldmine of Nephropathology Archives

G Bindi, L Pagani, J Ceku, GS de Oliveira… - Journal of Proteome …, 2024 - ACS Publications
The application of innovative spatial proteomics techniques, such as those based upon
matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) …