As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal
drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well …

Here we describe mechanisms regulating area patterning of develo** mammalian
neocortex, referred to as arealization. Current findings indicate an interplay between intrinsic …

Within the vertebrate nervous system, the presence of many different lineages of neurons
and glia complicates the molecular characterization of single neuronal populations. In order …

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …

During corticogenesis, early-born neurons of the preplate and layer 6 are important for
guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative …

Platelets are anucleated blood elements highly potent at generating extracellular vesicles
(EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The arealization of the mammalian cortex is believed to be controlled by a combination of
intrinsic factors that are expressed in the cortex, and external signals, some of which are …

The cellular properties of neural progenitor cells have been best characterized in the
telencephalon, the most complex region of the vertebrate brain. In recent years, several …

The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has
provided a conceptual framework for exploring the molecular mechanisms underlying …