Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

Cyclic attractors generated from Boolean models may explain the adaptability of a cell in
response to a dynamical complex tumor microenvironment. In contrast to this idea, we …

Discrete, logic-based models are increasingly used to describe biological mechanisms.
Initially introduced to study gene regulation, these models evolved to cover various …

As a result of the development of experimental technologies and the accumulation of data,
biological and molecular processes can be described as complex networks of signaling …

The balance between pro-and anti-inflammatory immune system responses is crucial to
preventing complex diseases like cancer. Macrophages are essential immune cells that …

Simple Summary Understanding the effects of the tumor microenvironment is an essential
step to advance treatments for cancer, but it is also one that is problematic to reproduce in …

Macrophages show high plasticity and result in heterogenic subpopulations or polarized
states identified by specific cellular markers. These immune cells are typically characterized …

Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism
against pathogens. In tumors, recent studies have uncovered complex macrophage …

Gene regulatory networks (GRNs) and mathematical modelling are critical for understanding
the complex regulatory mechanisms that underlie tumour development and progression …