[HTML][HTML] The emerging risk of microplastics and nanoplastics on the microstructure and function of reproductive organs in mammals: A systematic review of preclinical …

RC Marcelino, RM Cardoso, ELBC Domingues… - Life Sciences, 2022‏ - Elsevier
Aims Plastic particles (PP) pollution is a global environmental concern. Although the
reproductive toxicity of PP is primarily understood for invertebrates, the evidence for …

[HTML][HTML] Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence

TG de Souza-Silva, IA Oliveira, GG da Silva, FCV Giusti… - Life sciences, 2022‏ - Elsevier
Aims We systematically review the in vivo preclinical evidence on the impact of microplastics
(MPs) on the intestinal microbiota and morphofunctional changes involving the intestinal …

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review

A da Cunha Ignácio, AM dos Reis Guerra… - Food & Function, 2024‏ - pubs.rsc.org
Glyphosate is the most commercialized herbicide in Brazil and worldwide, and this has
become a worrying scenario in recent years. In 2015 glyphosate was classified as …

The impact of a western diet on gut microbiota and circadian rhythm: A comprehensive systematic review of in vivo preclinical evidence

MLM Gobis, TG de Souza-Silva, HA de Almeida Paula - Life Sciences, 2024‏ - Elsevier
Aims Here, we present a systematic review that compiles in vivo experimental data
regarding the effect of the WD on the gut microbiota and its impact on the circadian rhythm …

Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials

SS Nogueira, EC Santos, RO Silva, RV Gonçalves… - Parasitology, 2022‏ - cambridge.org
From a systematic review framework, we analysed the clinical evidence on the effectiveness
and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) …

Putative Inhibitor of TcCYP51 from a Library of Approved Drugs: A Virtual Screening Study

LAP Flores-Junior, EG Santos, EMF Muri… - Journal of the Brazilian …, 2024‏ - SciELO Brasil
Chagas disease is a public health problem, particularly in Latin America. The available
treatment consists of two poorly effective drugs in the chronic phase of this parasitic disease …

Effect of statins on inflammation and cardiac function in patients with chronic Chagas disease: A protocol for pathophysiological studies in a multicenter, placebo …

C Campos-Estrada, E Urarte, M Denegri, L Villalón… - Plos one, 2023‏ - journals.plos.org
Background Cardiac complications, including heart failure and arrhythmias, are the leading
causes of disability and death in Chagas disease (CD). CD, caused by the Trypanosoma …

[HTML][HTML] Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study

TG Souza-Silva, DF Vilas-Boas, E Gonçalves-Santos… - Life Sciences, 2020‏ - Elsevier
Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with
different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal …

Chronic rapamycin pretreatment modulates arginase/inducible nitric oxide synthase balance attenuating aging-dependent susceptibility to Trypanosoma cruzi …

M Pereira-Santos, E Gonçalves-Santos… - Experimental …, 2022‏ - Elsevier
Considering the efficacy of rapamycin in increasing lifespan and healthspan, attenuating the
aging-dependent immunological decline, we compared the evolution of Trypanosoma cruzi …

T-cell receptor variable region usage in Chagas disease: A systematic review of experimental and human studies

TG de Souza-Silva, KJ Gollob… - PLoS neglected tropical …, 2022‏ - journals.plos.org
T cells recognize their ligand, the peptide major histocompatibility complex (MHC), via the T-
cell receptor (TCR), which is composed of covalently linked α and β or γ and δ chains. This …