Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via
X-chromosome inactivation (XCI), initiating early in development. Although XCI events are …

High-resolution molecular programmes delineating the cellular foundations of mammalian
embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre …

Pig embryonic stem cells (pESCs) have been considered an important candidate for
preclinical research on human therapies. However, the lack of understanding of pig …

The inner cell mass (ICM) in blastocyst is the origin of all somatic and germ cells in
mammals and pluripotent stem cells (PSCs) in vitro. As the conserved principles between …

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Humans and rodents differ in how they carry out X inactivation (XI), the mammalian method
to compensate for the different number of X chromosomes in males and females …

A major factor limiting the development of somatic cell nuclear transfer (SCNT) technology is
the low success rate of pregnancy, mainly due to placental abnormalities disrupting the …

Background: Patients with systemic lupus erythematosus (SLE) often suffer from obstetric
complications not necessarily associated with the antiphospholipid syndrome. These events …

**st is an X-linked ribonucleic acid (RNA) gene responsible for the cis induction of X
chromosome inactivation (XCI). In cloned mammalian embryos, **stis ectopically activated …