Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-
presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

Given that cancer is one of the main causes of death worldwide, many efforts have been
directed toward discovering new treatments and approaches to cure or control this group of …

Metronomic (low-dose, long-term and frequently administered) chemotherapy has attracted
renewed interest for the past few years, in particular because of possible positive …

Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide,
constituting 6% of all cancers and the third leading cause of cancer death. CRC is the third …

The tumor microenvironment (TME) represents a complex interplay between different
cellular components, including tumor cells and cancer stem cells (CSCs), with the …

Immunotherapy is a promising antitumor strategy that can successfully be combined with
current anticancer treatment. In this study, arsenic trioxide (As 2 O 3) was shown to increase …

Gene immunotherapy has become an important approach in the treatment of cancer. One
example is the introduction of genes encoding immunostimulatory cytokines, such as …