Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

Periodontitis is a bacterial-induced, chronic inflammatory disease characterized by
progressive destruction of tooth-supporting structures. Pathogenic bacteria residing in deep …

Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic
homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their …

Glucocorticoids are widely used for their unsurpassed anti-inflammatory and
immunomodulatory effects. However, the therapeutic use of glucocorticoids is almost always …

Glucocorticoids prescribed to limit inflammation, have significant adverse effects. As 11β-
hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoid, we …

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …

Context: 11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes are now appreciated to
be important regulators of hormone action at a tissue level. 11β-HSD1 is widely expressed …

Calgranulins comprise three proteins, S100A8 (Calgranulin A), S100A9 (Calgranulin B) and
S100A12 (Calgranulin C) that are predominantly expressed by neutrophils, monocytes and …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …