Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Toxoplasmosis is the clinical and pathological consequence of acute infection with the
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …

Toxoplasma gondii is a parasite of humans and animals, and a model for other
apicomplexans including Plasmodium spp., the causative agents of malaria. Despite many …

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase
underpinned by timely and spatially controlled secretion of apical organelles termed …

Protein kinases regulate fundamental aspects of eukaryotic cell biology, making them
attractive chemotherapeutic targets in parasites like Plasmodium spp. and Toxoplasma …

Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …

Toxoplasma gondii possesses a limited set of actin-regulatory proteins and relies on only
three formins (FRMs) to nucleate and polymerize actin. We combined filamentous actin (F …