Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …

This review describes the functions, structures, and mechanisms of nine nickel-containing
enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase,[NiFe] …

Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Zinc fingers are small protein domains in which zinc plays a structural role contributing to the
stability of the domain. Zinc fingers are structurally diverse and are present among proteins …

Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …

Motivation Protein solubility plays a vital role in pharmaceutical research and production
yield. For a given protein, the extent of its solubility can represent the quality of its function …

The 3D structures of human therapeutic targets are enabling for drug discovery. However,
their purification and crystallization remain rate determining. In individual cases, ligands …

Increasing a protein concentration in solution to the required level, without causing
aggregation and precipitation is often a challenging but important task, especially in the field …

Intrinsically disordered proteins and regions carry out varied and vital cellular functions.
Proteins with disordered regions are especially common in eukaryotic cells, with a subset of …