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Theory and applications of differential scanning fluorimetry in early-stage drug discovery
Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …
technique that has seen many applications over the years, ranging from protein folding state …
[HTML][HTML] Stapled peptides inhibitors: a new window for target drug discovery
Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
An automated method for finding molecular complexes in large protein interaction networks
Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …
display and mass spectrometry have enabled us to create a detailed map of biomolecular …
DeepSol: a deep learning framework for sequence-based protein solubility prediction
Motivation Protein solubility plays a vital role in pharmaceutical research and production
yield. For a given protein, the extent of its solubility can represent the quality of its function …
yield. For a given protein, the extent of its solubility can represent the quality of its function …
Nickel-dependent metalloenzymes
This review describes the functions, structures, and mechanisms of nine nickel-containing
enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase,[NiFe] …
enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase,[NiFe] …
Structural classification of zinc fingers: survey and summary
Zinc fingers are small protein domains in which zinc plays a structural role contributing to the
stability of the domain. Zinc fingers are structurally diverse and are present among proteins …
stability of the domain. Zinc fingers are structurally diverse and are present among proteins …
SOLpro: accurate sequence-based prediction of protein solubility
Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …
sequence-based prediction method able to accurately predict the propensity of a protein to …
A simple method for improving protein solubility and long-term stability
Increasing a protein concentration in solution to the required level, without causing
aggregation and precipitation is often a challenging but important task, especially in the field …
aggregation and precipitation is often a challenging but important task, especially in the field …
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
The 3D structures of human therapeutic targets are enabling for drug discovery. However,
their purification and crystallization remain rate determining. In individual cases, ligands …
their purification and crystallization remain rate determining. In individual cases, ligands …
Comparing and combining predictors of mostly disordered proteins
Intrinsically disordered proteins and regions carry out varied and vital cellular functions.
Proteins with disordered regions are especially common in eukaryotic cells, with a subset of …
Proteins with disordered regions are especially common in eukaryotic cells, with a subset of …