Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target
adverse effects caused by various chemotherapeutic agents, such as cisplatin, oxaliplatin …

Behavior is shaped by both the internal state of an animal and its individual behavioral
biases. Rhythmic variation in gonadal hormones during the estrous cycle is a defining …

Neuropathic pain is a common pain syndrome, which seriously affects the quality of life of
patients. The mechanism of neuropathic pain is complex. Peripheral tissue injury can trigger …

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …

Inflammatory pain results from the heightened sensitivity and reduced threshold of
nociceptor sensory neurons due to exposure to inflammatory mediators. However, the …

Oncomodulin (Ocm) is a myeloid cell–derived growth factor that enables axon regeneration
in mice and rats after optic nerve injury or peripheral nerve injury, yet the mechanisms …

The sensory inflow from the periphery that triggers innocuous and painful sensations is
highly complex, capturing key elements of the nature of any stimulus, its location, intensity …

The anterolateral system (ALS) is a major ascending pathway from the spinal cord that
projects to multiple brain areas and underlies the perception of pain, itch, and skin …

Pain in rodents is often inferred from their withdrawal from noxious stimulation. Threshold
stimulus intensity or response latency is used to quantify pain sensitivity. This usually …

Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …