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Transcriptional regulation of secondary metabolite biosynthesis in plants
Plants produce thousands of secondary metabolites (aka specialized metabolites) of diverse
chemical nature. These compounds play important roles in protecting plants under adverse …
chemical nature. These compounds play important roles in protecting plants under adverse …
Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets
R Qin, FM You, Q Zhao, X **e, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …
signal transduction pathways and can be regulated by genetic signals or drug interventions …
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle
Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
M ercator: a fast and simple web server for genome scale functional annotation of plant sequence data
Next‐generation technologies generate an overwhelming amount of gene sequence data.
Efficient annotation tools are required to make these data amenable to functional genomics …
Efficient annotation tools are required to make these data amenable to functional genomics …
Hyb‐Seq: Combining target enrichment and genome skimming for plant phylogenomics
• Premise of the study: Hyb‐Seq, the combination of target enrichment and genome
skimming, allows simultaneous data collection for low‐copy nuclear genes and high‐copy …
skimming, allows simultaneous data collection for low‐copy nuclear genes and high‐copy …
Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution
P Li, MX Yan, P Liu, DJ Yang, ZK He, Y Gao, Y Jiang… - Molecular Plant, 2024 - cell.com
The Lamiaceae family is renowned for its terpenoid-based medicinal components, but
Leonurus, which has traditional medicinal uses, stands out for its alkaloid-rich composition …
Leonurus, which has traditional medicinal uses, stands out for its alkaloid-rich composition …
Genome‐guided investigation of plant natural product biosynthesis
The medicinal plant Madagascar periwinkle, C atharanthus roseus (L.) G. Don, produces
hundreds of biologically active monoterpene‐derived indole alkaloid (MIA) metabolites and …
hundreds of biologically active monoterpene‐derived indole alkaloid (MIA) metabolites and …
A differentially regulated AP 2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in …
Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIA s), including the
chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA …
chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA …
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
A Van Moerkercke, P Steensma, F Schweizer… - Proceedings of the …, 2015 - pnas.org
Plants make specialized bioactive metabolites to defend themselves against attackers. The
conserved control mechanisms are based on transcriptional activation of the respective …
conserved control mechanisms are based on transcriptional activation of the respective …