Transcriptional regulation of secondary metabolite biosynthesis in plants

B Patra, C Schluttenhofer, Y Wu, S Pattanaik… - Biochimica et Biophysica …, 2013 - Elsevier
Plants produce thousands of secondary metabolites (aka specialized metabolites) of diverse
chemical nature. These compounds play important roles in protecting plants under adverse …

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X **e, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

L Caputi, J Franke, SC Farrow, K Chung, RME Payne… - Science, 2018 - science.org
Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …

A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis

M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …

M ercator: a fast and simple web server for genome scale functional annotation of plant sequence data

M Lohse, A Nagel, T Herter, P May, M Schroda… - 2014 - Wiley Online Library
Next‐generation technologies generate an overwhelming amount of gene sequence data.
Efficient annotation tools are required to make these data amenable to functional genomics …

Hyb‐Seq: Combining target enrichment and genome skimming for plant phylogenomics

K Weitemier, SCK Straub, RC Cronn… - Applications in plant …, 2014 - Wiley Online Library
• Premise of the study: Hyb‐Seq, the combination of target enrichment and genome
skimming, allows simultaneous data collection for low‐copy nuclear genes and high‐copy …

Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution

P Li, MX Yan, P Liu, DJ Yang, ZK He, Y Gao, Y Jiang… - Molecular Plant, 2024 - cell.com
The Lamiaceae family is renowned for its terpenoid-based medicinal components, but
Leonurus, which has traditional medicinal uses, stands out for its alkaloid-rich composition …

Genome‐guided investigation of plant natural product biosynthesis

F Kellner, J Kim, BJ Clavijo, JP Hamilton… - The Plant …, 2015 - Wiley Online Library
The medicinal plant Madagascar periwinkle, C atharanthus roseus (L.) G. Don, produces
hundreds of biologically active monoterpene‐derived indole alkaloid (MIA) metabolites and …

A differentially regulated AP 2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in …

P Paul, SK Singh, B Patra, X Sui, S Pattanaik… - New …, 2017 - Wiley Online Library
Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIA s), including the
chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA …

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

A Van Moerkercke, P Steensma, F Schweizer… - Proceedings of the …, 2015 - pnas.org
Plants make specialized bioactive metabolites to defend themselves against attackers. The
conserved control mechanisms are based on transcriptional activation of the respective …