Characterizing protein-protein interactions with thermal proteome profiling
BC Searle - Current Opinion in Structural Biology, 2024 - Elsevier
Thermal proteome profiling (TPP) is an innovative technique that uses the principle of
protein thermal stability to identify potential protein interaction partners. Employing …
protein thermal stability to identify potential protein interaction partners. Employing …
Prospects of using protein engineering for selective drug delivery into a specific compartment of target cells
A large number of proteins are successfully used to treat various diseases. These include
natural polypeptide hormones, their synthetic analogues, antibodies, antibody mimetics …
natural polypeptide hormones, their synthetic analogues, antibodies, antibody mimetics …
[HTML][HTML] Modular Nanotransporters Deliver Anti-Keap1 Monobody into Mouse Hepatocytes, Thereby Inhibiting Production of Reactive Oxygen Species
Background/Objectives: The study of oxidative stress in cells and ways to prevent it attract
increasing attention. Antioxidant defense of cells can be activated by releasing the …
increasing attention. Antioxidant defense of cells can be activated by releasing the …
Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the …
YV Khramtsov, AV Ulasov, TN Lupanova… - Pharmaceutics, 2023 - mdpi.com
The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a
biologically active agent that provides the degradation of one of these key proteins and/or …
biologically active agent that provides the degradation of one of these key proteins and/or …
Modular Nanotransporters Delivering Biologically Active Molecules to the Surface of Mitochondria
Treatment of various diseases, in particular cancer, usually requires the targeting of
biologically active molecules at a selected subcellular compartment. We modified our …
biologically active molecules at a selected subcellular compartment. We modified our …
GALA3-Containing Modular Nanotransporters Are Capable of Delivering Keap1 Monobody to Target Cells and Inhibiting the Formation of Reactive Oxygen Species in …
YV Khramtsov, ES Bunin, AV Ulasov… - Doklady Biochemistry …, 2025 - Springer
In the previously created modular nanotransporter (MNT) capable of delivering a monobody
to Keap1 into the cytosol, the endosomolytic module, translocation domain of diphtheria …
to Keap1 into the cytosol, the endosomolytic module, translocation domain of diphtheria …
Quantitative Description of the N-Protein of the SARS-CoV-2 Virus Degradation in Cells Stably Expressing It under the Influence of New Modular Nanotransporters
YV Khramtsov, AV Ulasov, TN Lupanova… - Doklady Biochemistry …, 2023 - Springer
Two eukaryotic cell lines, A549 and A431, with stable expression of the nucleocapsid
protein (N-protein) of the SARS-CoV-2 virus fused with the red fluorescent protein mRuby3 …
protein (N-protein) of the SARS-CoV-2 virus fused with the red fluorescent protein mRuby3 …
[CITAS][C] Prospects of Using Protein Engineering for Selective Drug Delivery into a Specific Compartment of Target Cells. Pharmaceutics 2023, 15, 987
AA Rosenkranz, TA Slastnikova - 2023 - europepmc.org
A large number of proteins are successfully used to treat various diseases. These include
natural polypeptide hormones, their synthetic analogues, antibodies, antibody mimetics …
natural polypeptide hormones, their synthetic analogues, antibodies, antibody mimetics …