Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
As distinct cancer biomarkers have been discovered in recent years, a need to reclassify
tumors by more than their histology has been proposed, and therapies are now tailored to …
tumors by more than their histology has been proposed, and therapies are now tailored to …
Modulation of NRF2/KEAP1 signaling in preeclampsia
G Tossetta, S Fantone, F Piani, C Crescimanno… - Cells, 2023 - mdpi.com
Placentation is a key and tightly regulated process that ensures the normal development of
the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related …
the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related …
TROPHY-U-01: a phase II open-label study of sacituzumab govitecan in patients with metastatic urothelial carcinoma progressing after platinum-based chemotherapy …
ST Tagawa, AV Balar, DP Petrylak… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Patients with metastatic urothelial carcinoma (mUC) who progress on platinum-
based combination chemotherapy (PLT) and checkpoint inhibitors (CPIs) have limited …
based combination chemotherapy (PLT) and checkpoint inhibitors (CPIs) have limited …
Role of NRF2 in ovarian cancer
G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers
G Tossetta, D Marzioni - European Journal of Pharmacology, 2023 - Elsevier
Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …
The role of NQO1 in ovarian cancer
Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high
fatality rate because of late diagnosis and relapse occurrence due to chemoresistance …
fatality rate because of late diagnosis and relapse occurrence due to chemoresistance …
Role of CD93 in Health and Disease
CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is
a transmembrane glycoprotein encoded by a gene located on 20p11. 21 and composed of …
a transmembrane glycoprotein encoded by a gene located on 20p11. 21 and composed of …
Metformin improves ovarian cancer sensitivity to paclitaxel and platinum-based drugs: a review of in vitro findings
G Tossetta - International Journal of Molecular Sciences, 2022 - mdpi.com
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide, showing a
high fatality rate and recurrence due to diagnosis at an advanced stage of the disease and …
high fatality rate and recurrence due to diagnosis at an advanced stage of the disease and …
Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast …
H Dong, J Hu, K Zou, M Ye, Y Chen, C Wu, X Chen… - Molecular cancer, 2019 - Springer
Background Trastuzumab resistance followed by metastasis is a major obstacle for
improving the clinical outcome of patients with advanced human epidermal growth factor …
improving the clinical outcome of patients with advanced human epidermal growth factor …
Trop2: Jack of all trades, master of none
Simple Summary Metastatic progression represents a major clinical challenge and remains
the leading cause of death in cancer patients. Identification of suitable therapeutic targets …
the leading cause of death in cancer patients. Identification of suitable therapeutic targets …