SARS-CoV-2 biology and host interactions
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
TTD: Therapeutic Target Database describing target druggability information
Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for develo** first-in-class drug. A variety …
identification of promising targets is fundamental for develo** first-in-class drug. A variety …
Molecular virology of SARS-CoV-2 and related coronaviruses
SUMMARY Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to …
syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to …
A proteome-scale map of the SARS-CoV-2–human contactome
Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …
Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several
outbreaks have occurred in the last decades. Although several receptors and co-receptors …
outbreaks have occurred in the last decades. Although several receptors and co-receptors …
Exploring the expanding universe of host-virus interactions mediated by viral RNA
RNA is a central molecule in RNA virus biology; however, the interactions that it establishes
with the host cell are only starting to be elucidated. In recent years, a methodology revolution …
with the host cell are only starting to be elucidated. In recent years, a methodology revolution …
SARS-CoV-2 variants of concern hijack IFITM2 for efficient replication in human lung cells
It has recently been shown that an early SARS-CoV-2 isolate (NL-02-2020) hijacks
interferon-induced transmembrane proteins (IFITMs) for efficient replication in human lung …
interferon-induced transmembrane proteins (IFITMs) for efficient replication in human lung …
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Climate change and population densities accelerated transmission of highly pathogenic
viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here …
viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here …
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning
WD40 repeat-containing protein 91 (WDR91) regulates early-to-late endosome conversion
and plays vital roles in endosome fusion, recycling, and transport. WDR91 was recently …
and plays vital roles in endosome fusion, recycling, and transport. WDR91 was recently …