Micro and nanoscale technologies in oral drug delivery

S Ahadian, JA Finbloom, M Mofidfar, SE Diltemiz… - Advanced drug delivery …, 2020 - Elsevier
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to
administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery …

Non-invasive drug delivery technology: Development and current status of transdermal drug delivery devices, techniques and biomedical applications

N Akhtar, V Singh, M Yusuf, RA Khan - Biomedical Engineering …, 2020 - degruyter.com
Pay-load deliveries across the skin barrier to the systemic circulation have been one of the
most challenging delivery options. Necessitated requirements of the skin and facilitated skin …

Micro/nanofabricated platforms for oral drug delivery

CB Fox, J Kim, LV Le, CL Nemeth, HD Chirra… - Journal of Controlled …, 2015 - Elsevier
The oral route of drug administration is most preferred due to its ease of use, low cost, and
high patient compliance. However, the oral uptake of many small molecule drugs and …

[HTML][HTML] Formulation strategies to improve the efficacy of intestinal permeation enhancers

S Maher, DJ Brayden - Advanced Drug Delivery Reviews, 2021 - Elsevier
The use of chemical permeation enhancers (PEs) is the most widely tested approach to
improve oral absorption of low permeability active agents, as represented by peptides …

Reservoir-based drug delivery systems utilizing microtechnology

CL Stevenson, JT Santini Jr, R Langer - Advanced drug delivery reviews, 2012 - Elsevier
This review covers reservoir-based drug delivery systems that incorporate microtechnology,
with an emphasis on oral, dermal, and implantable systems. Key features of each …

Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo

RT Steipel, MD Gallovic, CJ Batty, EM Bachelder… - Materials Science and …, 2019 - Elsevier
Also known as electrospray, electrohydrodynamic atomization has been used extensively in
the last 15 years to develop polymer-based particles for drug delivery in cell and animal …

[HTML][HTML] Physical methods for enhancing drug absorption from the gastrointestinal tract

Z Luo, N Paunović, JC Leroux - Advanced Drug Delivery Reviews, 2021 - Elsevier
Overcoming the gastrointestinal (GI) barriers is a formidable challenge in the oral delivery of
active macromolecules such as peptide-and protein-based drugs. In the past four decades …

Microfabrication technologies for oral drug delivery

S Sant, SL Tao, OZ Fisher, Q Xu, NA Peppas… - Advanced drug delivery …, 2012 - Elsevier
Micro-/nanoscale technologies such as lithographic techniques and microfluidics offer
promising avenues to revolutionalize the fields of tissue engineering, drug discovery …

Intestinal permeation enhancers to improve oral bioavailability of macromolecules: Reasons for low efficacy in humans

S Maher, C Geoghegan, DJ Brayden - Expert Opinion on Drug …, 2021 - Taylor & Francis
ABSTRACT Introduction Intestinal permeation enhancers (PEs) are substances that
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …

Microfabricated devices for oral drug delivery

LH Nielsen, SS Keller, A Boisen - Lab on a Chip, 2018 - pubs.rsc.org
Oral administration of drugs is most convenient for patients and therefore the ultimate goal
when develo** new medication. The physical barriers in the body, low pH of the stomach …