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Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery
Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins,
various functions, and unique lipid and protein compositions have been introduced as …
various functions, and unique lipid and protein compositions have been introduced as …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are sha** how we study and target Tauopathies
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Mechanisms of secretion and spreading of pathological tau protein
CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
[HTML][HTML] Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation
JJ Chen, DL Nathaniel, P Raghavan, M Nelson… - Journal of Biological …, 2019 - Elsevier
Intercellular propagation of protein aggregation is emerging as a key mechanism in the
progression of several neurodegenerative diseases, including Alzheimer's disease and …
progression of several neurodegenerative diseases, including Alzheimer's disease and …
Membrane-induced tau amyloid fibrils
The intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in
human brains afflicted with Alzheimer's disease and other neurodegenerative diseases. Tau …
human brains afflicted with Alzheimer's disease and other neurodegenerative diseases. Tau …
[HTML][HTML] Microglia in Alzheimer's disease in the context of tau pathology
JR Perea, M Bolós, J Avila - Biomolecules, 2020 - mdpi.com
Microglia are the cells that comprise the innate immune system in the brain. First described
more than a century ago, these cells were initially assigned a secondary role in the central …
more than a century ago, these cells were initially assigned a secondary role in the central …
Much more than a cytoskeletal protein: physiological and pathological functions of the non-microtubule binding region of tau
Tau protein (MAPT) is classified as a microtubule-associated protein (MAP) and is believed
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …
Site‐specific hyperphosphorylation inhibits, rather than promotes, tau fibrillization, seeding capacity, and its microtubule binding
The consistent observation of phosphorylated tau in the pathology of Alzheimer's disease
has contributed to the emergence of a model where hyperphosphorylation triggers both tau …
has contributed to the emergence of a model where hyperphosphorylation triggers both tau …
Tau and membranes: interactions that promote folding and condensation
Tau misfolding and assembly is linked to a number of neurodegenerative diseases
collectively described as tauopathies, including Alzheimer's disease (AD) and Parkinson's …
collectively described as tauopathies, including Alzheimer's disease (AD) and Parkinson's …