Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

A Shafqat, I Albalkhi, HM Magableh, T Saleh… - Frontiers in cellular …, 2023 - frontiersin.org
Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

Two decades of heart regeneration research: cardiomyocyte proliferation and beyond

H Huang, GN Huang… - WIREs Mechanisms of …, 2024 - Wiley Online Library
Interest in vertebrate cardiac regeneration has exploded over the past two decades since
the discovery that adult zebrafish are capable of complete heart regeneration, contrasting …

Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

R Shkhyan, C Flynn, E Lamoure, A Sarkar… - Science translational …, 2023 - science.org
Adult mammals are incapable of multitissue regeneration, and augmentation of this potential
may shift current therapeutic paradigms. We found that a common co-receptor of interleukin …

The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor

DG Mitchell, A Edgar, JR Mateu, JF Ryan… - Communications …, 2024 - nature.com
Regenerative potential is widespread but unevenly distributed across animals. However, our
understanding of the molecular mechanisms underlying regenerative processes is limited to …

Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

T Koopmans, H van Beijnum, EF Roovers… - NPJ Regenerative …, 2021 - nature.com
Ischemic heart disease and by extension myocardial infarction is the primary cause of death
worldwide, warranting regenerative therapies to restore heart function. Current models of …

Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear

H van Beijnum, T Koopmans, A Tomasso… - Genome …, 2023 - genome.cshlp.org
In contrast to other mammals, the spiny mouse (Acomys) regenerates skin and ear tissue,
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …

Osteoderms in a mammal the spiny mouse Acomys and the independent evolution of dermal armor

M Maden, T Polvadore, A Polanco, WB Barbazuk… - Iscience, 2023 - cell.com
Osteoderms are bony plates found in the skin of vertebrates, mostly commonly in reptiles
where they have evolved independently multiple times, suggesting the presence of a gene …

What is next in African neuroscience?

KA Donald, M Maina, N Patel, C Nguemeni… - Elife, 2022 - elifesciences.org
Working in Africa provides neuroscientists with opportunities that are not available in other
continents. Populations in this region exhibit the greatest genetic diversity; they live in …

Fibroblast yap/taz signaling in extracellular matrix homeostasis and tissue fibrosis

CQ Chu, T Quan - Journal of Clinical Medicine, 2024 - mdpi.com
Tissue fibrosis represents a complex pathological condition characterized by the excessive
accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired …

Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration

BM Kidd, JA Varholick, DM Tuyn, PK Kamat… - npj Regenerative …, 2024 - nature.com
Stroke is a major cause of disability for adults over 40 years of age. While research into
animal models has prioritized treatments aimed at diminishing post-stroke damage, no …