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Tackling the glial scar in spinal cord regeneration: new discoveries and future directions
Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …
by the formation of an injury scar. While this scar was traditionally believed to be primarily …
Two decades of heart regeneration research: cardiomyocyte proliferation and beyond
H Huang, GN Huang… - WIREs Mechanisms of …, 2024 - Wiley Online Library
Interest in vertebrate cardiac regeneration has exploded over the past two decades since
the discovery that adult zebrafish are capable of complete heart regeneration, contrasting …
the discovery that adult zebrafish are capable of complete heart regeneration, contrasting …
Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis
R Shkhyan, C Flynn, E Lamoure, A Sarkar… - Science translational …, 2023 - science.org
Adult mammals are incapable of multitissue regeneration, and augmentation of this potential
may shift current therapeutic paradigms. We found that a common co-receptor of interleukin …
may shift current therapeutic paradigms. We found that a common co-receptor of interleukin …
The ctenophore Mnemiopsis leidyi deploys a rapid injury response dating back to the last common animal ancestor
DG Mitchell, A Edgar, JR Mateu, JF Ryan… - Communications …, 2024 - nature.com
Regenerative potential is widespread but unevenly distributed across animals. However, our
understanding of the molecular mechanisms underlying regenerative processes is limited to …
understanding of the molecular mechanisms underlying regenerative processes is limited to …
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
T Koopmans, H van Beijnum, EF Roovers… - NPJ Regenerative …, 2021 - nature.com
Ischemic heart disease and by extension myocardial infarction is the primary cause of death
worldwide, warranting regenerative therapies to restore heart function. Current models of …
worldwide, warranting regenerative therapies to restore heart function. Current models of …
Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear
In contrast to other mammals, the spiny mouse (Acomys) regenerates skin and ear tissue,
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …
Osteoderms in a mammal the spiny mouse Acomys and the independent evolution of dermal armor
Osteoderms are bony plates found in the skin of vertebrates, mostly commonly in reptiles
where they have evolved independently multiple times, suggesting the presence of a gene …
where they have evolved independently multiple times, suggesting the presence of a gene …
What is next in African neuroscience?
Working in Africa provides neuroscientists with opportunities that are not available in other
continents. Populations in this region exhibit the greatest genetic diversity; they live in …
continents. Populations in this region exhibit the greatest genetic diversity; they live in …
Fibroblast yap/taz signaling in extracellular matrix homeostasis and tissue fibrosis
Tissue fibrosis represents a complex pathological condition characterized by the excessive
accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired …
accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired …
Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration
Stroke is a major cause of disability for adults over 40 years of age. While research into
animal models has prioritized treatments aimed at diminishing post-stroke damage, no …
animal models has prioritized treatments aimed at diminishing post-stroke damage, no …