Alzheimer's disease (AD) is the most common type of dementia in the elderly. Several
hypotheses emerged from AD pathophysiological mechanisms. However, no neuronal …

Over the course of most common neurodegenerative diseases the amygdala accumulates
pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is …

Multiple different pathological protein aggregates are frequently seen in human postmortem
brains and hence mixed pathology is common. Mixed dementia on the other hand is less …

Post-mortem investigations of human Alzheimer's disease (AD) have largely failed to
provide unequivocal evidence in support of the original amyloid cascade hypothesis, which …

The term oligomeropathies defines the neurodegenerative disorders associated with protein
misfolding, where small soluble aggregates (oligomers 4‐200 KDa) are the cause of …

Alzheimer's disease (AD) is the most common cause of dementia among older adults.
Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its …

Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …

Pyroglutamate-modified amyloid-β (pE-Aβ) is a highly neurotoxic amyloid-β (Aβ) isoform and
is enriched in the brains of individuals with Alzheimer disease compared with healthy aged …

Last year marked 25 years of research into the amyloid hypothesis of Alzheimer's disease
(AD)(Selkoe and Hardy, 2016). Over the last few years, studies on this subject have …

Somatic mutations during stem cell division are responsible for several cancers. In principle,
a similar process could occur during the intense cell proliferation accompanying human …