Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in develo** cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

The emerging antioxidant paradigm of mesenchymal stem cell therapy

R Stavely, K Nurgali - Stem Cells Translational Medicine, 2020 - academic.oup.com
Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for
the treatment of diverse diseases, with many promising outcomes achieved in animal …

Why are MSCs therapeutic? New data: new insight

AI Caplan - The Journal of Pathology: A Journal of the …, 2009 - Wiley Online Library
Adult marrow‐derived mesenchymal stem cells (MSCs) are able to differentiate into bone,
cartilage, muscle, marrow stroma, tendon–ligament, fat and other connective tissues. The …

Notch signaling in the regulation of stem cell self-renewal and differentiation

J Liu, C Sato, M Cerletti, A Wagers - Current topics in developmental …, 2010 - Elsevier
Stem cells are rare and unique precursor cells that participate in the building and rebuilding
of tissues and organs during embryogenesis, postnatal growth, and injury repair. Stem cells …

Human mesenchymal stem cells efficiently manage oxidative stress

A Valle-Prieto, PA Conget - Stem cells and development, 2010 - liebertpub.com
The transplantation of mesenchymal stem cells (MSCs) proves to be useful to treat
pathologies in which tissue damage is linked to oxidative stress (OS). The aim of our work …

Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy

J Varghese, M Griffin, A Mosahebi, P Butler - Stem cell research & therapy, 2017 - Springer
Background The applications for fat grafting have increased recently, within both
regenerative and reconstructive surgery. Although fat harvesting, processing and injection …

Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species

S Achuthan, TR Santhoshkumar, J Prabhakar… - Journal of Biological …, 2011 - ASBMB
Tumor recurrence after chemotherapy or radiation remains a major obstacle to successful
cancer treatment. A subset of cancer cells, termed cancer stem cells, can elude conventional …

Concise review: adult multipotent stromal cells and cancer: risk or benefit?

G Lazennec, C Jorgensen - Stem cells, 2008 - academic.oup.com
This review focuses on the interaction between multipotent stromal cells (MSCs) and
carcinoma and the possible use of MSCs in cell-based anticancer therapies. MSCs are …

The role of mesenchymal stem cells in radiation-induced lung fibrosis

M Zanoni, M Cortesi, A Zamagni, A Tesei - International journal of …, 2019 - mdpi.com
Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …