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Immune evasion and provocation by Mycobacterium tuberculosis
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …
The use of RNA-based treatments in the field of cancer immunotherapy
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
Pathogenicity and virulence of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
Immune cell interactions in tuberculosis
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …
(Mtb) vaccine, provides limited durable protection when administered intradermally …
Clinical manifestations and immune response to tuberculosis
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …
Key advances in vaccine development for tuberculosis—success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …
Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille …
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille …
Age and sex influence antibody profiles associated with tuberculosis progression
Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such
as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody …
as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody …
Transforming vaccinology
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global
consciousness, emphasizing the vital role of vaccines as transformative public health tools …
consciousness, emphasizing the vital role of vaccines as transformative public health tools …