Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …

Melatonin is present in virtually all organisms from bacteria to mammals, and it exhibits a
broad spectrum of biological functions, including synchronization of circadian rhythms and …

A new glucose-responsive formulation for self-regulated insulin delivery was constructed by
packing insulin, glucose-specific enzymes into pH-sensitive polymersome-based …

Highlights•The concept that PepT1 serves as a drug transporter has been further
substantiated.•Significant progress has been made on drugs such as cefadroxil and …

The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role
in the absorption of small peptides including not only> 400 different dipeptides and 8,000 …

Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Seventeen CDDO–amino acid–NO donor trihybrids (4a–q) were designed and synthesized.
Biological evaluation indicated that the most active compound 4c produced high levels of …

With the global population rising, the need for sustainable and resource-efficiently produced
proteins with nutritional and health promoting qualities has become urgent. Proteins are …

The oligopeptide/histidine transporters PHT1 and PHT2, two mammalian solute carrier
family 15A proteins, mediate the transmembrane transport of histidine and some …